Why is this so hilarious? What's the missing context?

Saw this on Reddit though I'd ask you guys since your in it.

Whats it mean?

In my chemistry class, I don't have a clue what it means

Guys I just don't get it. I'm just as puzzled as the guy in the photo.

was on my seminar professor’s home page; any ideas???

Text on image: (title) “Who’s There?” (cartoonist/illustrator)”Lynda Barry, copyright 2000” (caption/punchline) “Maybonne stares in the mirror a lot. What is she looking at? I don’t think it’s just her face.”

What am i missing?

I keep seeing this meme on twitter but i dont get it

“To hell with everything I studied”

I’m a philosophy grad but I still don’t get it. It says “To hell with/fuck/(literally) I shit on everything I studied”

No Irish... I don't get it

My mom got this wedding invitation in the mail. None of us know what "no irish" means. I'm hoping it's a joke we don't get

My stupid friends told me another "joke" I don't get, please help me

Why?