I’m stumped on this one

This makes no sense

I have no clue

I feel like it's getting worse

I don’t get it.

Apparently I don’t have ultra high knowledge

Why is this so hilarious? What's the missing context?

Saw this on Reddit though I'd ask you guys since your in it.

Whats it mean?

In my chemistry class, I don't have a clue what it means

Guys I just don't get it. I'm just as puzzled as the guy in the photo.